MicroRNA-495 Regulates Migration and Invasion in Prostate Cancer Cells Via Targeting Akt and mTOR Signaling
收藏DataCite Commons2020-09-04 更新2024-07-25 收录
下载链接：
https://figshare.com/articles/MicroRNA_495_Regulates_Migration_and_Invasion_in_Prostate_Cancer_Cells_Via_Targeting_Akt_and_mTOR_Signaling/3145111/1
下载链接
链接失效反馈官方服务：
资源简介：
Abnormal microRNA (miR) expressions were implicated in prostate cancer progression. We identified a novel miR-495, which was downregulated in prostate cancer, but not normal prostate cell lines. MiR-495 directly targeted the 3′-UTR of Akt and mTOR mRNAs. Expression of miR-495 in prostate cancer cells significantly downregulated Akt and mTOR, which further inhibited cancer cell proliferation, migration, and invasion <i>in vitro</i>. Function of miR-495 <i>in vivo</i> was examined in mouse xenograft model and was found to significantly inhibit the growth of tumors, mediated by repressing Akt and mTOR. Our report supported miR-495 as a novel tumor suppressor microRNA in prostate cancer.
提供机构：
Taylor & Francis
创建时间：
2016-03-31
