Source data: Olive leaf extract ameliorates hyperglycaemia, oxidative stress, and pancreatic and hepatic injury in streptozotocin-induced diabetic rats (animal-level dataset, n = 48)

Animal-level source data for the study "Olive Leaf Extract Ameliorates Hyperglycaemia, Oxidative Stress, and Pancreatic and Hepatic Injury in Streptozotocin-Induced Diabetic Rats: A Dose-Dependent Comparison with Metformin." Forty-eight male Wistar rats were randomised to six groups (n = 8): Normal, Normal + olive leaf extract (OLE) 400 mg/kg, Diabetic, Diabetic + OLE 200 mg/kg, Diabetic + OLE 400 mg/kg, and Diabetic + metformin 200 mg/kg. The workbook contains per-animal fasting blood glucose, HbA1c, serum insulin, HOMA-IR and HOMA-beta, OGTT time-course and AUC, separate pancreatic and hepatic oxidative-stress markers (MDA, GSH, SOD, CAT), semi-quantitative histopathology scores, hepatic congestion-area morphometry, animal biometrics (body weight, food and water intake), a serum liver and kidney function panel (ALT, AST, ALP, creatinine), omnibus ANOVA and post-hoc results, a statistical annex, the HPLC method, reagent and kit details, and a methods-values sheet. Version 3 provided independently scored pancreatic and hepatic histopathology (correcting an earlier version in which liver injury scores duplicated the pancreatic scores in several groups); the summary medians/IQR and Kruskal-Wallis statistics (pancreas H = 42.49, liver H = 39.64) were updated accordingly. Version 4 adds two further per-animal datasets: animal biometrics (body weight, food and water intake) and a serum liver/kidney function panel (ALT, AST, ALP, creatinine), corresponding to the additional manuscript tables. Provided to support the corresponding manuscript submitted to FARMACIA (Romanian Society of Pharmaceutical Sciences). Licensed CC BY 4.0.