Crystal structure of the P450 BM3 heme domain mutant F87A/T268P/V78I in complex with N-imidazolyl-pentanoyl-L-phenylalanine,propylbenzene and hydroxylamine

Crystal structure of the P450 BM3 heme domain mutant F87A/T268P/V78I in complex with N-imidazolyl-pentanoyl-L-phenylalanine,propylbenzene and hydroxylamine Descriptor: (2~{S})-2-(5-imidazol-1-ylpentanoylamino)-3-phenyl-propanoic acid, HYDROXYAMINE, P450 BM3 heme domain mutant F87A/T268P/V78I, ... Authors: Dong, S, Chen, J, Jiang, Y, Cong, Z, Feng, Y. Deposit date: 2022-07-04 Release date: 2023-05-24 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.663 Å) Cite: Regiodivergent and Enantioselective Hydroxylation of C-H bonds by Synergistic Use of Protein Engineering and Exogenous Dual-Functional Small Molecules. Angew.Chem.Int.Ed.Engl., 62, 2023

本数据集为与N-咪唑基戊酰基-L-苯丙氨酸、丙基苯及羟胺结合的P450 BM3血红素结构域突变体F87A/T268P/V78I（P450 BM3 heme domain mutant F87A/T268P/V78I）的晶体结构。相关描述：(2S)-2-(5-咪唑-1-基戊酰氨基)-3-苯基丙酸、羟胺、P450 BM3血红素结构域突变体F87A/T268P/V78I……。作者：Dong, S、Chen, J、Jiang, Y、Cong, Z、Feng, Y。提交日期：2022-07-04，发布日期：2023-05-24，最后修改日期：2023-11-29。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.663埃。引用文献：《通过协同使用蛋白质工程与外源性双功能小分子实现C-H键的区域发散性与对映选择性羟化反应》，Angew.Chem.Int.Ed.Engl.，2023年，第62卷。