A gain-of-function JAK2V617F mutation is found in the vast majority of patients with polycythemia vera (PV) and in 50-60% of those with essential thrombocythemia (ET) or idiopathic myelofibrosis (IMF)

NIAID Data Ecosystem70

Dataset associated with 'Interactions between callose and cellulose revealed through the analysis of biopolymer mixtures'

植物细胞壁生物学

相互作用分析

The properties of (1,3)-β-glucans (i.e. callose) remain largely unknown despite their importance in plant development and defence. Mixtures of (1,3)-β-glucan and cellulose, in ionic liquid solution an

DataCite Commons2025-01-27 更新50

Physical interaction between mutant calreticulin and the thrombopoietin receptor is required for transformation of hematopoietic cells. Mus musculus

骨髓增殖性肿瘤

癌症信号通路

Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with myeloproliferative neoplasms (MPN). However, the mechanism by which mutant CALR is oncogenic is unknown. Here

NIAID Data Ecosystem70

Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms. Jak2V617F Reversible Activation Shows an Essential Requirement for Jak2V617F in Myeloproliferative Neoplasms

骨髓增殖性肿瘤

JAK2V617F突变

Janus kinases (JAKs) mediate cytokine signaling, cell growth and hematopoietic differentiation. Gain-of-function mutations activating JAK2 signaling are seen in the majority of myeloproliferative neop

NIAID Data Ecosystem60

Supplementary Table S10 from Trisomy 8 Defines a Distinct Subtype of Myeloproliferative Neoplasms Driven by the MYC–Alarmin Axis

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