TNF can trigger two opposing responses: cell survival and cell death. TNFR1 activates caspases that orchestrate apoptosis but some cell types switch to a necrotic death when treated with caspase inhib

NIAID Data Ecosystem40

Expression data from sorted Treg cells from WT or motheaten mice

调节性T细胞功能

免疫调节分子机制

The importance of regulatory T cells (Treg) for immune tolerance is well recognized, yet the signaling molecules influencing their suppressive activity are relatively poorly understood. We identified

NIAID Data Ecosystem30

Cytokine expression in lymph nodes of WT and Lcn-2 KO mice 7 days after NTS induction.

免疫调节分子机制

基因表达分析

WT (n = 13) and Lcn-2 KO mice (n = 12) were subjected to NTS and followed for 7 days. cDNA isolated from lymph nodes was analyzed for the expression of the respective genes. The respective gene/HPRT r

NIAID Data Ecosystem50

The volume regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling

细胞信号传导

免疫调节分子机制

The volume-regulated anion channel (VRAC) is a hexameric complex formed by LRRC8 proteins. VRACs are responsible for the regulatory volume decrease (RVD) after hypotonic cell swelling by mediating the

NIAID Data Ecosystem30

Role of Adenosine 2A Receptors (A2AR) on regulatory T cells (Tregs)

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