Identification and analysis of microRNA editing events in recurrent bladder cancer based on RNA sequencing: microRNA editing level is a potential novel biomarker

To identify and compare miRNA editing events in primary and recurrent bladder cancer, as well as to investigate the potential molecular mechanism and its impact on patient prognosis. We examined the mRNA and miRNA transcriptomes of 12 recurrent bladder cancer cases and 13 primary bladder cancer cases. Overall design: In this study, we performed RNA sequencing on tissue specimens from 25 bladder cancer(BC) patients (12 recurrent BC and 13 primary BC) and performed a comprehensive analysis of mRNAseq and miRNAseq to determine miRNA editing in bladder cancer.