List of replicated (uncorrected p<0.05) associations in the IMAS cohort.

Among all replicated associations in the IMAS sample, the most significant association of each analyte in the ADNI sample is listed in the same order as they are listed in the Table 3 for easy comparison. In case the most significant SNPs in the ADNI sample was not replicated in the IMAS sample, the most significant association in the IMAS sample is listed. R2SNP, which is the fraction of variation accounted for by SNP while adjusting for the effect of covariates, is defined as follows: R2SNP = adjusted R2 of model with SNP and covariates – adjusted R2 of model with covariates.SNP: Single Nucleotide Polymorphism; IMAS: Indiana Memory and Aging Study; Chr: Chromosome.*Gene and SNP information are based on the Genome Build 37.3.**Tested genetic model: Additive (ADD), Dominant (DOM).***SNP with smallest p in the IMAS, but not in the ADNI.♣Gene-protein pairs in the initial and updated annotation are shown together.