Additional file 1 of From tobacco smoking to cancer mutational signature: a mediation analysis strategy to explore the role of epigenetic changes

Additional file 1: Table S1. The sample size for each cancer from TCGA. Table S2. A collection of candidate blood-based methylations at CpG sites reported from five previous epigenome wide association studies. Table S3. A list of 374 candidate blood-based methylation CpG sites and genes identified from both discovery and replication studies at an adjusted P < 0.05. Table S4. Associations between smoking-associated mutational signature and expression of candidate genes for each cancer type (P < 0.05). Table S5. Associations between tobacco smoking and expression of candidate genes and as methylation of candidate CpG sites. Table S6. Association of expression of candidate genes and their isoforms with methylation at each CpG site. Table S7. Correlation between expressions of AHRR and its isoforms. Table S8. Cox regression analysis between gene expression and overall survival in lung cancer patients. Table S9. Associations between smoking-associated mutational signature and predicted neoantigen load for each cancer type.