Targeting Histone K4 Trimethylation for Treatment of Cognitive and Synaptic Deficits of Mouse Models of Alzheimer's Disease (RNA-seq)

We performed RNAseq experiments to examine genome-wide transcriptional changes in PFC of P301S Tau mice with or without WDR5-0103 treatment. Overall design: mRNA via RNAseq analysis of two 6 mo. old PS19(P301S), and two 6 mo. old control (C57BL/6 x C3H), and two 6 mo. old PS19P301S) treated with WDR5-0103 mice from PFC tissue were compared.