Promoter hypermethylation in MLL-r leukemia: biology and therapeutic targeting

ChEBI2009-12-29 更新2026-07-21 收录

白血病表观遗传学

肿瘤靶向治疗

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-19671 数据链接链接失效反馈

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资源简介：

Promoter hypermethylation in MLL-r leukemia: biology and therapeutic targeting

创建时间：

2009-12-29

BET inhibition releases the Mediator complex from specific cis elements in acute myeloid leukemia cells (ChIP-Seq II)

白血病表观遗传学

染色质免疫沉淀测序

Genome occupancy profiling by high throughput sequencing ChIP-seq of Brd4 with or without Doxycycline treatment to induce Med12 or Med23 shRNAs in MLL-AF9 transformed acute myeloid leukemia cells (RN2

NIAID Data Ecosystem110

肿瘤靶分子临床研究信息数据集

肿瘤靶向治疗

临床研究

聚焦肿瘤靶分子临床研究全流程，整合靶点发现、临床试验设计、疗效数据、安全性评估等核心信息。数据经标准化清洗与专业校验，关联靶点分子结构、作用机制及临床结果，支持科研机构靶点验证、药企药物研发、临床机构方案优化，为靶分子临床转化提供高质量、可溯源的数据支撑。

江苏数据交易所80

Additional file 7 of Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia

白血病表观遗传学

基因突变关联分析

Additional file 7: Table S3. Pairwise associations between driver mutations presented by Pearson's Correlation Coefficient (cor) and p-value (p).

NIAID Data Ecosystem70

SAM Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance

肿瘤靶向治疗

药物耐药机制

Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell c

NIAID Data Ecosystem90

Effect of DNMT3A R882H mutation or WT on gene expression in hematopoietic stem/progenitor cells with NRAS G12D co-transduction (Microarray). Mus musculus

细胞恶性转化

白血病表观遗传学

DNA Methyltransferase 3A (DNMT3A) is frequently mutated in various hematopoietic malignancies; however, the underlying oncogenic mechanisms remain elusive. Here, we report that DNMT3A mutational ‘hots

NIAID Data Ecosystem70

Promoter hypermethylation in MLL-r leukemia: biology and therapeutic targeting

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