Prmt1 supports antibody affinity maturation and represses plasma cell differentiation

NIAID Data Ecosystem2026-05-01 收录

B细胞分化

抗体亲和力成熟

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP136609 数据链接链接失效反馈

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资源简介：

RNAseq on B cells from HSC to GC B cell Overall design: B cells from HSC to GC B cell

创建时间：

2023-04-28

Data_Sheet_1_RNA and Toll-Like Receptor 7 License the Generation of Superior Secondary Plasma Cells at Multiple Levels in a B Cell Intrinsic Fashion.PDF

B细胞分化

疫苗开发

Secondary plasma cells (PCs) originate from memory B cells and produce increased levels of antibodies with higher affinity compared to PCs generated during primary responses. Here we demonstrate that

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mTORC1 kinase activity dictates B-1a versus B-2 cell lineage commitment

B细胞分化

mTORC1信号通路

CD5+ B-1a cells is a dominant population of innate-like B cells that play critical roles in innate defense and immune regulation. In our model, mTORC1 enhances B-1a cells development and differentiati

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Single-cell characterization of transcriptomic heterogeneity in human tonsillar B-cell subsets

单细胞转录组学

B细胞分化

BFL-1 is an understudied anti-apoptotic protein that is upregulated in melanoma, certain forms of leukemias and lymphomas, and Epstein-Barr virus (EBV)-immortalized lymphoblastoid cell lines (LCLs). W

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Stage Specific Non-coding RNA Expression Patterns During in vitro Human B Cell Differentiation into Antibody Secreting Plasma Cells

B细胞分化

非编码RNA分析

The differentiation of activated B cells into antibody secreting plasma cells (PCs) is governed by a strict regulatory network that results in expression of specific transcriptomes along the continuum

NIAID Data Ecosystem30

scRNA-seq time course of B cell differentiation in organoid cultures

B细胞分化

单细胞转录组学

To understand how different stimulation conditions impacted the maturation of B cells and formation of plasma cells in an ex vivo organoid culture, we preformed 10X single-cell RNA-seq comparing the C

NIAID Data Ecosystem10

Prmt1 supports antibody affinity maturation and represses plasma cell differentiation

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