Crystal structure of the M. abscessus LeuRS editing domain in complex with epetraborole-AMP adduct

Crystal structure of the M. abscessus LeuRS editing domain in complex with epetraborole-AMP adduct Descriptor: Leucine--tRNA ligase, SULFATE ION, [(1S,5R,6R,7'S,8R)-7'-(aminomethyl)-6-(6-aminopurin-9-yl)-2'-(3-oxidanylpropoxy)spiro[2,4,7-trioxa-3-boranuidabicyclo[3.3.0]octane-3,9'-8-oxa-9-boranuidabicyclo[4.3.0]nona-1(6),2,4-triene]-8-yl]methyl dihydrogen phosphate Authors: Kalthoff, E, Schmeing, T.M. Deposit date: 2021-05-26 Release date: 2021-10-06 Last modified: 2026-02-04 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Efficacy of epetraborole against Mycobacterium abscessus is increased with norvaline. Plos Pathog., 17, 2021

脓肿分枝杆菌（Mycobacterium abscessus）亮氨酰-tRNA合成酶（Leucine--tRNA ligase, LeuRS）编辑结构域与埃替硼唑-腺苷一磷酸（epetraborole-AMP）加合物的晶体结构
描述：亮氨酰-tRNA连接酶、硫酸根离子、[(1S,5R,6R,7'S,8R)-7'-(氨甲基)-6-(6-氨基嘌呤-9-基)-2'-(3-羟基丙氧基)螺[2,4,7-三氧杂-3-硼杂双环[3.3.0]辛烷-3,9'-8-氧杂-9-硼杂双环[4.3.0]壬-1(6),2,4-三烯]-8-基]甲基二氢磷酸酯
作者：Kalthoff, E、Schmeing, T.M.
提交日期：2021-05-26
发布日期：2021-10-06
最后修改日期：2026-02-04
实验方法：X射线衍射（分辨率1.7 Å）
引用文献：诺瓦尔氨酸可增强埃替硼唑抗脓肿分枝杆菌的活性. 《公共科学图书馆·病原体》, 17卷, 2021