CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH C2(=NN(c1cccc(c1)[S](=O)(=O)C)C=CC2=O)c3ccnn3c4cccc5c4OC(O5)(F)F, micromolar IC50=0.029598

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH C2(=NN(c1cccc(c1)[S](=O)(=O)C)C=CC2=O)c3ccnn3c4cccc5c4OC(O5)(F)F, micromolar IC50=0.029598 Descriptor: 3-[1-(2,2-difluoro-2H-1,3-benzodioxol-4-yl)-1H-pyrazol-5-yl]-1-[3-(methanesulfonyl)phenyl]pyridazin-4(1H)-one, CHLORIDE ION, GLYCEROL, ... Authors: Joseph, C, Benz, J, Flohr, A, Rodriguez-Sarmiento, R.M, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published

人类磷酸二酯酶10（human phosphodiesterase 10）与配体C2(=NN(c1cccc(c1)[S](=O)(=O)C)C=CC2=O)c3ccnn3c4cccc5c4OC(O5)(F)F形成复合物的晶体结构，该配体的微摩尔级半数抑制浓度（IC50）为0.029598。描述符：3-[1-(2,2-二氟-2H-1,3-苯并二氧杂环戊烯-4-基)-1H-吡唑-5-基]-1-[3-(甲磺酰基)苯基]哒嗪-4(1H)-酮、氯离子（CHLORIDE ION）、甘油（GLYCEROL）等。作者：Joseph C、Benz J、Flohr A、Rodriguez-Sarmiento R.M、Rudolph M.G。沉积日期：2022-02-01；发布日期：2022-10-12；最后修改日期：2024-10-16。解析方法：X射线衍射（X-RAY DIFFRACTION），分辨率为2.1埃（Å）。引用信息：《人类磷酸二酯酶10复合物的晶体结构》，待发表。