The double-edged role of FASII regulator FabT in Streptococcus pyogenes infection. Streptococcus pyogenes strain:emm28

In Streptococcus pyogenes, the type II fatty acid (FA) synthesis pathway FASII is feedback-controlled by the FabT repressor. A FabT mutation leads to FASII dysregulation, FAs membrane modification and bacterial growth defect in the presence of eukaryotic cells and their supernatant. We try to understand the consequences on bacteria metabolism.