SUPPLEMENTAL INFORMATION - Impacts of antibiotic exposure and its changes on immune-mediated skin diseases in infants and children: A nationwide population-based cohort study
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Supplementary Table I. Hazard ratios for immune-mediated skin diseases according to the specific antibiotic classes compared to antibiotic non-user in infants and children Supplementary Table II. Subgroup analyses of the association between antibiotic use and immune-mediated skin diseases in infants and children Supplementary Table III. Sensitivity analyses of the association of antibiotic use with immune-mediated skin diseases among infants and children without autoimmune comorbidities Supplementary Table IV. Sensitivity analyses of the association of antibiotic use with immune-mediated skin diseases among infants and children using washout periods following the index date Supplementary Table V. Sensitivity analyses of the association of antibiotic use with atopic dermatitis among infants and children according to the infection comorbidities Supplementary Table VI. Sensitivity analyses of the association of antibiotic use with psoriasis among infants and children according to the infection comorbidities Supplementary Table VII. Sensitivity analyses of the association of antibiotic use with vitiligo among infants and children according to the infection comorbidities Supplementary Fig 1. Association between the changes in cumulative days of antibiotic exposure and pediatric immune-mediated skin diseases, including (A) atopic dermatitis, (B) psoriasis, and (C) vitiligo, among infants and children with no autoimmune comorbidities Supplementary Fig 2. Association between the changes in cumulative days of antibiotic exposure and pediatric immune-mediated skin diseases, including (A) atopic dermatitis, (B) psoriasis, and (C) vitiligo, among infants and children with 1-year washout period after index date Supplementary Fig 3. Association between the changes in cumulative days of antibiotic exposure and pediatric immune-mediated skin diseases, including (A) atopic dermatitis, (B) psoriasis, and (C) vitiligo, among infants and children with 2-year washout period after index date Supplementary Fig 4. Association between the changes in cumulative days of antibiotic exposure and risk of atopic dermatitis among infants and children with infection diseases, including (A) respiratory diseases, (B) urinary tract infections, (C) infections involving the skin, soft tissue, bone, or joint, and (D) other infections Supplementary Fig 5. Association between the changes in cumulative days of antibiotic exposure and risk of psoriasis among infants and children with infection diseases, including (A) respiratory diseases, (B) urinary tract infections, (C) infections involving the skin, soft tissue, bone, or joint, and (D) other infections Supplementary Fig 6. Association between the changes in cumulative days of antibiotic exposure and risk of vitiligo among infants and children with infection diseases, including (A) respiratory diseases, (B) urinary tract infections, (C) infections involving the skin, soft tissue, bone, or joint, and (D) other infections
补充表I. 相较于未使用抗生素的婴幼儿，按特定抗生素类别划分的免疫介导性皮肤病的风险比（Hazard Ratio） 补充表II. 婴幼儿抗生素使用与免疫介导性皮肤病关联的亚组分析 补充表III. 无合并自身免疫病的婴幼儿中，抗生素使用与免疫介导性皮肤病关联的敏感性分析 补充表IV. 按索引日期（Index Date）后设置洗脱期（Washout Period）的婴幼儿群体中，抗生素使用与免疫介导性皮肤病关联的敏感性分析 补充表V. 按合并感染症划分的婴幼儿中，抗生素使用与特应性皮炎（Atopic Dermatitis）关联的敏感性分析 补充表VI. 按合并感染症划分的婴幼儿中，抗生素使用与银屑病（Psoriasis）关联的敏感性分析 补充表VII. 按合并感染症划分的婴幼儿中，抗生素使用与白癜风（Vitiligo）关联的敏感性分析 补充图1. 无合并自身免疫病的婴幼儿中，抗生素累积暴露天数变化与儿童免疫介导性皮肤病的关联，其中（A）为特应性皮炎，（B）为银屑病，（C）为白癜风 补充图2. 索引日期后设置1年洗脱期的婴幼儿群体中，抗生素累积暴露天数变化与儿童免疫介导性皮肤病的关联，其中（A）为特应性皮炎，（B）为银屑病，（C）为白癜风 补充图3. 索引日期后设置2年洗脱期的婴幼儿群体中，抗生素累积暴露天数变化与儿童免疫介导性皮肤病的关联，其中（A）为特应性皮炎，（B）为银屑病，（C）为白癜风 补充图4. 合并感染性疾病的婴幼儿中，抗生素累积暴露天数变化与特应性皮炎发病风险的关联，其中（A）为呼吸系统疾病，（B）为尿路感染，（C）为皮肤、软组织、骨骼或关节感染，（D）为其他感染 补充图5. 合并感染性疾病的婴幼儿中，抗生素累积暴露天数变化与银屑病发病风险的关联，其中（A）为呼吸系统疾病，（B）为尿路感染，（C）为皮肤、软组织、骨骼或关节感染，（D）为其他感染 补充图6. 合并感染性疾病的婴幼儿中，抗生素累积暴露天数变化与白癜风发病风险的关联，其中（A）为呼吸系统疾病，（B）为尿路感染，（C）为皮肤、软组织、骨骼或关节感染，（D）为其他感染
