Staphylococcus aureus Dihydrofolate Reductase complexed with beta-NADPH, cyclic alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1106)
收藏Protein Data Bank Japan2023-09-27 更新2026-03-21 收录
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Staphylococcus aureus Dihydrofolate Reductase complexed with beta-NADPH, cyclic alpha-NADPH anomer and 3'-(3-(2,4-diamino-6-ethylpyrimidin-5-yl)prop-2-yn-1-yl)-4'-methoxy-[1,1'-biphenyl]-4-carboxylic acid (UCP1106) Descriptor: 4-[3-[3-[2,4-bis(azanyl)-6-ethyl-pyrimidin-5-yl]prop-2-ynyl]-4-methoxy-phenyl]benzoic acid, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... Authors: Anderson, A.C, Reeve, S.M. Deposit date: 2016-03-15 Release date: 2017-06-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (1.723 Å) Cite: Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations. J. Med. Chem., 59, 2016
金黄色葡萄球菌（Staphylococcus aureus）二氢叶酸还原酶（Dihydrofolate Reductase）与β-烟酰胺腺嘌呤二核苷酸磷酸（beta-NADPH）、环状α-NADPH异头体以及3'-(3-(2,4-二氨基-6-乙基嘧啶-5-基)丙-2-炔-1-基)-4'-甲氧基-[1,1'-联苯]-4-羧酸（UCP1106）形成的复合物。
描述项：4-[3-[3-[2,4-二氨基-6-乙基嘧啶-5-基]丙-2-炔基]-4-甲氧基苯基]苯甲酸、二氢叶酸还原酶（Dihydrofolate Reductase）、烟酰胺腺嘌呤二核苷酸磷酸（NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADP）等。
作者：Anderson, A.C.、Reeve, S.M.
入库日期：2016-03-15
发布日期：2017-06-28
最后修改日期：2023-09-27
实验方法：X射线衍射（分辨率1.723 Å）
引用文献：《带电荷炔丙基连接的抗叶酸剂揭示抗叶酸耐药机制并抑制携带临床相关突变的甲氧西林耐药金黄色葡萄球菌菌株》，《药物化学杂志》（J. Med. Chem.），59卷，2016年
创建时间：
2016-03-15
