HVN1904 MOVER Metadata Record - Musseling-up 2.0: Greenshell™ mussels for inflammation, metabolism and muscular skeletal function. Investigating the effect of long-term New Zealand green shell mussel powder consumption on promoting the recovery of muscle function following a bout of exercise-induced muscle damage to the quadriceps in untrained healthy males.

This metadata record and it's attached files make statements about the kinds of data collected as part of this research, and set out policies for governance of that data, now and in the future.Description: Prolonged and unaccustomed eccentric muscular work (like downhill walking) produces micro-structural damage to muscles resulting in inflammation and delayed soreness. Muscle damage from this exercise is associated with impaired muscle function (i.e. loss of muscle strength and mobility) and localised swelling/oedema. Although the mechanisms behind eccentric muscle damage are not precisely known, it is believed that along with initial mechanically induced disruption, secondary damage is caused by the inflammatory process and oxidative stress from inflammatory cells recruited to the site of injury. New Zealand green shell mussel (GSM) is rich in omega-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) which have been demonstrated to have anti-inflammatory properties. Green shell mussel contains additional bioactive components including glycosaminoglycans and other novel peptides and lipids that modulate inflammatory processes. Previous dietary intervention studies have reported the efficacy of New Zealand GSM to modulate key inflammatory factors leading to reduced soreness following exercise and improved lung function through reduced bronchoconstriction. These findings highlight the potential for New Zealand GSM supplementation to modulate exercise-induced inflammation and support recovery of muscle function following muscle damage. In this study, we seek to investigate the effect of long-term New Zealand GSM dietary supplementation in modulating inflammation and inflammatory pathways following exercise-induced muscle damage to the quadriceps. We will aim to examine whether any modulation in inflammation by GSM consumption leads to expedited recovery of musculo-skeletal performance following muscle damage.

本元数据记录及其所附文件阐述了作为本项研究一部分所收集的数据类型，并确立了该数据的管理政策，包括当前及未来。描述：长期且不习惯的外周肌肉运动（如下山行走）会导致肌肉发生微结构损伤，进而引起炎症和延迟性疼痛。此类运动引起的肌肉损伤与肌肉功能受损（即肌肉力量和活动能力下降）以及局部肿胀/水肿有关。尽管外周肌肉损伤的机制尚不明确，但普遍认为，除了初始的机械性破坏外，由炎症过程和炎症细胞在损伤部位的招募引起的氧化应激也导致了继发性损伤。新西兰绿壳贻贝（GSM）富含欧米茄-3脂肪酸二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），这些成分已被证明具有抗炎特性。绿壳贻贝还含有其他生物活性成分，包括糖胺聚糖以及其他新型肽和脂质，这些成分能够调节炎症过程。先前关于饮食干预的研究报告了新西兰GSM在调节关键炎症因子方面的有效性，这有助于减轻运动后的疼痛并改善肺功能，减少支气管痉挛。这些发现突显了新西兰GSM补充剂在调节运动诱导的炎症和促进肌肉损伤后肌肉功能恢复方面的潜力。在本研究中，我们旨在探讨长期新西兰GSM饮食补充剂在调节运动诱导的四头肌损伤后炎症和炎症通路中的作用。我们将旨在考察GSM摄入是否能在调节炎症方面产生作用，从而加速肌肉损伤后肌骨骼性能的恢复。