Gene expression profiles in the liver of obese AIM+/+ and AIM-/- mice

To elucidate differential preventive roles of the blood apoptosis inhibitor of macrophage (AIM) protein in fat deposition and hepatocarcinoma development, we have performed microarray analysis to assess putative difference in expression of genes related to carcinogenesis in the liver of AIM+/+ and AIM-/- fed a high-fat diet (HFD) for various periods. RNA was isolated from the liver of AIM+/+ and AIM-/- mice fed an HFD for 0, 6, 12, and 20 weeks, and analyzed by microarray.