Genome-wide CRISPR screening

NIAID Data Ecosystem2026-03-12 收录

CRISPRi筛选

冠状病毒宿主因子

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA752869 数据链接链接失效反馈

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资源简介：

A genome-wide CRISPR screening was performed in mouse haploid embryonic stem cells infected with pseudorabies virus, an alpha-herpesvirus causing human and pig diseases.

创建时间：

2021-08-08

An Arrayed CRISPR Screen Identifies Knockout Combinations Improving Antibody Productivity in HEK293 Cells

抗体生产优化

CRISPRi筛选

Mammalian cells are used to express complex biologics, such as multispecific antibodies. While multispecifics enable promising new strategies for treating human disease, their production at high expre

NIAID Data Ecosystem30

Genome-scale CRISPRi Perturb-seq on both unstimulated and stimulated Jurkat cells reveals regulators of human T-cell signaling

T细胞信号传导调控

CRISPRi筛选

The goal of the experiment is to identify genes involved in T-cell receptor (TCR) signaling and T-cell activation in human T cells. The Jurkat E6 cell line, engineered to express dCas9-KRAB and transd

NIAID Data Ecosystem20

Genes of CRISPR-Cas9 negative screening.

CRISPRi筛选

肿瘤免疫逃逸

We compared changes in sgRNA abundance between T24 cells challenged and unchallenged by CD8+ T cells, and then performed negative screening (p < 0.01, log2Fold change < −1.0, and good sgRNAs ≥ 5). (X

NIAID Data Ecosystem10

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [TargetedCRISPRscreen]

白血病发病机制

CRISPRi筛选

Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe

NIAID Data Ecosystem30

Essential gene profiles for human pluripotent stem cells identify uncharacterized genes and substrate dependencies. Mair et al.

干细胞鉴定

CRISPRi筛选

Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms,

NIAID Data Ecosystem20

Genome-wide CRISPR screening

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