Corrected and uncorrected REPs relative to NQO, as well as respective corrected and uncorrected EC25 values in the micronucleus assay with RTL-W1 cells.

Chemical losses in the micronucleus assay used for calculation of corrected EC25 (i.e. by multiplying the residual compound fraction with the EC25) and REP values were derived from GC-MS measurements in 6-well microplates without cells.n.d.: Inactive in assay system, i.e. substances which did not reach 25% induction of the NQO standard; n.a.: not available; STD: standard substance; LOQ: limit of quantification.1Maximun tested concentrations based on cytotoxicity data from Hinger & Brinkmann et al.[13].