Characterization of mitochondrial proteome in human langherans cells

Please provide an overall description of your study, think something similar in scope to the manuscript abstractPhysical and functional interactions between the cells and their substrate, defined as mechanotransduction, still represent a developing frontier of life sciences, despite the growing consensus for the relevance in the control of gene regulation and cell state. In this framework, the overall goal of this project was to identify and functionally characterise at the molecular level the mechanotransductive pathways, connecting the cellular microenvironment and the nucleus of Langherans cells, and to monitor the accompanying modulations in mitochondrial-related cell energetics by a proteomic approach.