Copper Hydroperoxo Species Activated by Hydrogen-Bonding Interaction with Its Distal Oxygen

A novel copper(II)−OOH complex with functional ligand that can form a hydrogen bond with the distal oxygen of hydroperoxide has been designed and prepared as a structural/functional model of dopamine β-hydroxylases, whose spectroscopic characterization and decomposition rates have indicated that the hydroperoxide is activated through the hydrogen-bonding interaction with the distal oxygen.