Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with (1R,2S,3S,4R,6R)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside

Crystal structure of a methyltransferase involved in the biosynthesis of gentamicin in complex with (1R,2S,3S,4R,6R)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside Descriptor: (1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2-deoxy-alpha-D-glucopyranoside, MAGNESIUM ION, Putative gentamicin methyltransferase, ... Authors: Bury, P, Huang, F, Leadlay, P, Dias, M.V.B. Deposit date: 2016-11-28 Release date: 2017-11-01 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.902 Å) Cite: Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis. ACS Chem. Biol., 12, 2017

参与庆大霉素生物合成的甲基转移酶与(1R,2S,3S,4R,6R)-4,6-二氨基-3-{[3-脱氧-4-C-甲基-3-(甲氨基)-β-L-阿拉伯吡喃糖基]氧基}-2-羟基环己基 2-氨基-2-脱氧-α-D-吡喃葡萄糖苷形成复合物的晶体结构
配体描述：(1R,2S,3S,4R,6S)-4,6-二氨基-3-{[3-脱氧-4-C-甲基-3-(甲氨基)-β-L-阿拉伯吡喃糖基]氧基}-2-羟基环己基 2-氨基-2-脱氧-α-D-吡喃葡萄糖苷、镁离子、推定庆大霉素甲基转移酶……
作者：Bury, P、Huang, F、Leadlay, P、Dias, M.V.B.
沉积日期：2016-11-28
发布日期：2017-11-01
最后修改日期：2023-10-04
解析方法：X射线衍射（1.902 Å）
引用文献：《参与庆大霉素生物合成的氨基糖苷N-甲基转移酶GenN的选择性结构基础》，发表于ACS Chem. Biol.，12卷，2017年