Supplementary online content for Manuscript: "Nicotinamide for Skin Cancer Chemoprevention - The Jury Was Out and Still Is"

These files represent formal evidence synthesis using the ROBINS-I V2 tool (https://www.riskofbias.info/welcome/robins-i-v2) and the NIH/NHLBI Quality Assessment Tool for Before–After (Pre–Post) Studies With No Control Group (https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools) eTable1 represents a summary of the detailed Risk of Bias assessment highlighting the strengths and limitations of each domain. A traffic light vector is included for each domain. eTable2 represents the detailed, 42-page document of the Risk of Bias Assessment. eTable3 represents the Risk of Bias assessment using the NIH/NHLBI Quality Assessment Tool for Before–After (Pre–Post) Studies With No Control Group (https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools). ROBINS-I V2 is not designed for single arm cohort studies and thus cannot be used.