Human brain expression correlations between levels of LRRTM3, and CTNNA3, BACE1 or APP.

Multivariable linear regression analyses were conducted while controlling for technical variables (plate, RIN), biological variables (diagnosis, age, sex, APOE4 dose) and variables accounting for cell loss, gliosis and vascularity by including as covariates expression levels of genes highly expressed in neurons (ENO2), astrocytes (GFAP), oligodendrocytes (OLIG2), microglia (CD68) and endothelial cell (CD34). The brain levels of CTNNA3, BACE1 or APP were used as the outcome variable in a model, which included the above covariates and LRRTM3 brain expression levels. Gene expression levels were detected in both the temporal cortex and cerebellum, for which results are shown separately. The significance (p), effect size (Beta) and 95% confidence interval of the effect size (95%CI) of LRRTM3 expression for each of the tested genes are shown. Significant results are highlighted. Negative beta reflects an inverse relationship and positive correlation have a positive beta.