Oxidative C–H/N–H Annulation of Aromatic Amides with Dialkyl Malonates: Access to Isoindolinones and Dihydrobenzoindoles
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A copper-mediated oxidative C–H/N–H annulation of aromatic amides with dialkyl malonates has been presented to afford synthetically valuable dihydrobenzoindoles and isoindolinones. The reaction proceeds through direct oxidative C(sp2)–H/C(sp3)–H coupling followed by an intramolecular N–H/C(sp3)–H dehydrogenative coupling to deliver the target motifs with broad scope and functional group tolerance.
创建时间：
2020-04-01
