HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor

HIV-1 protease in complex with fluoro substituted diol-based C2- symmetric inhibitor Descriptor: (2R,3R,4R,5R)-2,5-BIS[(2,5-DIFLUOROBENZYL)OXY]-3,4-DIHYDROXY-N,N'-BIS[(1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL]HEXANEDIAMIDE, POL POLYPROTEIN Authors: Lindberg, J, Pyring, D, Loewgren, S, Rosenquist, A, Zuccarello, G, Kvarnstroem, I, Zhang, H, Vrang, L, Claesson, B, Hallberg, A, Samuelsson, B, Unge, T. Deposit date: 2004-08-10 Release date: 2004-10-07 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Symmetric Fluoro-Substituted Diol-Based HIV Protease Inhibitors. Ortho-Fluorinated and Meta-Fluorinated P1/P1'-Benzyloxy Side Groups Significantly Improve the Antiviral Activity and Preserve Binding Efficacy Eur.J.Biochem., 271, 2004

与氟取代二醇类C₂对称抑制剂结合的HIV-1蛋白酶（HIV-1 protease）
描述物：(2R,3R,4R,5R)-2,5-双[(2,5-二氟苄基)氧基]-3,4-二羟基-N,N'-双[(1S,2R)-2-羟基-2,3-二氢-1H-茚-1-基]己二酰胺，POL多聚蛋白（POL polyprotein）
作者：Lindberg, J、Pyring, D、Loewgren, S、Rosenquist, A、Zuccarello, G、Kvarnstroem, I、Zhang, H、Vrang, L、Claesson, B、Hallberg, A、Samuelsson, B、Unge, T
提交日期：2004-08-10
发布日期：2004-10-07
最后修改日期：2024-05-08
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.9埃（Å）
引用文献：《对称氟取代二醇类HIV蛋白酶抑制剂：邻氟与间氟取代的P1/P1'-苄氧基侧链可显著提升抗病毒活性并保持结合效力》，《欧洲生物化学杂志》（Eur.J.Biochem.），第271卷，2004年