Dynamic Kinetic Resolution-Based Asymmetric Transfer Hydrogenation of 2‑Benzoylmorpholinones and Its Use in Concise Stereoselective Synthesis of All Four Stereoisomers of the Antidepressant Reboxetine
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https://figshare.com/articles/dataset/Dynamic_Kinetic_Resolution_Based_Asymmetric_Transfer_Hydrogenation_of_2_Benzoylmorpholinones_and_Its_Use_in_Concise_Stereoselective_Synthesis_of_All_Four_Stereoisomers_of_the_Antidepressant_Reboxetine/2379580
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资源简介：
Dynamic kinetic resolution-driven,
asymmetric transfer hydrogenation
reaction of 2-benzoylmorpholin-3-ones (4) proceeds efficiently
to give the corresponding (2R,3S)- or (2S,3R)-2-(hydroxyphenylmethyl)morpholin-3-ones
(6) with an excellent level of diastereo- and enantioselectivity
and simultaneous control of two contiguous stereogenic centers in
a single step. This process is employed to prepare all four stereoisomers
of the antidepressant reboxetine.
创建时间：
2016-02-18
