A primate-specific ELOA3 gene cluster augments sensitivity to BET bromodomain inhibition. A primate-specific ELOA3 gene cluster augments sensitivity to BET bromodomain inhibition

We have identified a cluster of ELOA3 gene homologs that are activated upon treatment with BET bromodomain inhibitors and mediate sensitivity to BET inhibition. Overall design: We have performed ChIP-seq for ELOA3, RNA polymerase II (RNAPII) and other transcription elongation factors. In addition we have performed RNA-sequencing in ELOA3 loss-of-function and gain-of-function experiments.