Structure of Methionyl-tRNA Synthetase in complex with 1-(4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(4,5-dimethoxy-2-methylphenoxy)pyrimidin-2-yl}piperazin-1-yl)ethanone

Protein Data Bank Japan2024-02-28 更新2026-03-21 收录

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Structure of Methionyl-tRNA Synthetase in complex with 1-(4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(4,5-dimethoxy-2-methylphenoxy)pyrimidin-2-yl}piperazin-1-yl)ethanone Descriptor: 1-(4-{4-[(1H-benzimidazol-2-ylmethyl)amino]-6-(4,5-dimethoxy-2-methylphenoxy)pyrimidin-2-yl}piperazin-1-yl)ethanone, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... Authors: Hilgers, M.T. Deposit date: 2014-06-30 Release date: 2015-07-29 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Discovery and SAR of a Novel Series of Pyrimidine Antibacterials Targeting Methionyl-tRNA Synthetase to be published

与1-(4-{4-[(1H-苯并咪唑-2-基甲基)氨基]-6-(4,5-二甲氧基-2-甲基苯氧基)嘧啶-2-基}哌嗪-1-基)乙酮结合的甲硫氨酰-tRNA合成酶（Methionyl-tRNA Synthetase）的晶体结构。描述符：1-(4-{4-[(1H-苯并咪唑-2-基甲基)氨基]-6-(4,5-二甲氧基-2-甲基苯氧基)嘧啶-2-基}哌嗪-1-基)乙酮、腺苷-5'-三磷酸（ADENOSINE-5'-TRIPHOSPHATE）、镁离子（MAGNESIUM ION）等。作者：Hilgers, M.T.。提交日期：2014-06-30；发布日期：2015-07-29；最后修改日期：2024-02-28。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.7 Å。引用文献：《靶向甲硫氨酰-tRNA合成酶的新型嘧啶类抗菌剂的发现与构效关系研究》（待发表）

创建时间：

2014-06-30