Dihydrodipicolinate synthase (DHDPS) from C.jejuni, E88A mutant with pyruvate bound in the active site and R,R-bislysine at the allosteric site

Dihydrodipicolinate synthase (DHDPS) from C.jejuni, E88A mutant with pyruvate bound in the active site and R,R-bislysine at the allosteric site Descriptor: (2R,5R)-2,5-diamino-2,5-bis(4-aminobutyl)hexanedioic acid, 1,2-ETHANEDIOL, 4-hydroxy-tetrahydrodipicolinate synthase, ... Authors: Saran, S, Sanders, D.A.R. Deposit date: 2020-11-06 Release date: 2021-11-17 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.28 Å) Cite: THE ALLOSTERIC SITE RESIDUE, E88 INTERACTS WITH THE INHIBITORS TO TRANSMIT THE ALLOSTERIC INHIBITION SIGNALS IN Cj.DHDPS BY FORMING A HYDROGEN BOND. To Be Published

来自空肠弯曲菌（C.jejuni）的二氢二吡啶甲酸合酶（Dihydrodipicolinate synthase, DHDPS）E88A突变体，其活性位点结合丙酮酸，别构位点结合R,R-双赖氨酸。组分描述：(2R,5R)-2,5-二氨基-2,5-双(4-氨基丁基)己二酸、1,2-乙二醇、4-羟基四氢二吡啶甲酸合酶等。作者：萨兰（Saran, S）、桑德斯（Sanders, D.A.R.）。提交日期：2020-11-06；发布日期：2021-11-17；最后修改日期：2023-11-29。检测方法：X射线衍射（2.28埃）。引用说明：待发表文献《空肠弯曲菌DHDPS中别构位点残基E88通过形成氢键与抑制剂相互作用以传递别构抑制信号》