Candidozyma auris strains microevolved in the presence of micafungin

NIAID Data Ecosystem2026-05-10 收录

抗真菌耐药性

体外微进化

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP597222 数据链接链接失效反馈

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资源简介：

Candidozyma auris micafungin resistant strains created in the presence of micafungin via in vitro microevolution.

创建时间：

2025-10-17

Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance.

表观遗传学

抗真菌耐药性

Epe1 histone demethylase restricts H3K9-methylation-dependent heterochromatin, preventing it from spreading over, and silencing, gene-containing regions in fission yeast. External stress induces an ad

NIAID Data Ecosystem80

Candida auris UCLA isolates

念珠菌分离株

抗真菌耐药性

Candida auris UCLA isolates

NIAID Data Ecosystem50

Identification of genome wide alternative splicing events in sequential, isogenic clinical isolates of C. albicans reveals a novel mechanism of drug resistance and tolerance to cellular stresses.

微生物可变剪接

抗真菌耐药性

Identification of genome wide alternative splicing events in sequential, isogenic clinical isolates of C. albicans reveals a novel mechanism of drug resistance and tolerance to cellular stresses.

NIAID Data Ecosystem20

Exploring comparative and transcriptomic analyses to unveil mechanisms of resistance to azoles dependent and independent of CgPdr1 in Candida glabrata clinical isolates

抗真菌耐药性

光滑念珠菌转录组学

The pathogenic yeast species Candida glabrata has an intrinsically high resilience to azoles and a rapid capability of acquiring resistance. Azole-resistant clinical strains derive mostly from them en

NIAID Data Ecosystem50

The caspofungin paradoxical effect is a tolerant "Eagle effect" in the filamentous fungal pathogen Aspergillus fumigatus

抗真菌耐药性

烟曲霉菌致病机制

Cell responses against antifungals different from resistance have been rarely studied in filamentous fungi, while terms such as tolerance and persistence are well-described for bacteria and increasing

NIAID Data Ecosystem30

Candidozyma auris strains microevolved in the presence of micafungin

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