Medications with Established Human Anxiolytic Effects.

+At least one placebo-controlled study with the preponderance demonstrating an anxiolytic effect; -At least one placebo-controlled study with the preponderance not finding an anxiolytic effect; +/− At least one placebo-controlled study and the findings are equivocal and/or there is no clear preponderance of positive or negative results; ? No placebo-controlled studies have been carried out. PD = Panic Disorder; GAD = Generalized Anxiety Disorder; PTSD = Post-Traumatic Stress Disorder; and SAD = Social Anxiety Disorder. *Although there are a number of positive studies with SSRIs, the Institute of Medicine concluded that there was insufficient evidence to support the efficacy of SSRIs in PTSD due to moderate effect sizes [8], [27], [28], [30], [35], [38], [46]–[52].