Figure S1 - Salvianolic Acid B Prevents Bone Loss in Prednisone-Treated Rats through Stimulation of Osteogenesis and Bone Marrow Angiogenesis

Working scheme: the mechanism of action of Salvianolic acid B on glucocorticoid induced bone loss. Decrease of osteogenesis and angiogenesis, increase of adipogenesis are considered contributions to glucocorticoid induced bone loss. Salvianolic acid B could withstand the impairment induced by glucocorticoid. (BMPs: bone morphogenetic proteins; MSCs: marrow stromal cells; PPARγ: peroxisome proliferator-activated receptor γ; VEGF: vascular endothelial growth factor; Black: effect of glococorticoid; Red: effect of Salvianolic acid B; ↑: increase; ↓: decrease). (DOC)