Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z71580604 (A71EV2A-x0416)

Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z71580604 (A71EV2A-x0416) Descriptor: (2S)-N-(5-methylpyridin-2-yl)oxolane-2-carboxamide, DIMETHYL SULFOXIDE, Protease 2A, ... Authors: Lithgo, R.M, Fairhead, M, Koekemoer, L, Balcomb, B.H, Capkin, E, Chandran, A.V, Golding, M, Godoy, A.S, Aschenbrenner, J.C, Marples, P.G, Ni, X, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. Deposit date: 2024-04-04 Release date: 2024-04-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.28 Å) Cite: Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024

柯萨奇病毒A16（Coxsackievirus A16）G-10株2A蛋白酶晶体学片段筛选集群提交数据集——结合配体Z71580604（A71EV2A-x0416）的柯萨奇病毒A16 G-10株2A蛋白酶晶体结构
描述项：(2S)-N-(5-甲基吡啶-2-基)四氢呋喃-2-甲酰胺、二甲基亚砜（Dimethyl Sulfoxide）、2A蛋白酶（Protease 2A）等
作者：Lithgo, R.M.、Fairhead, M、Koekemoer, L、Balcomb, B.H、Capkin, E、Chandran, A.V、Golding, M、Godoy, A.S、Aschenbrenner, J.C、Marples, P.G、Ni, X、Thompson, W、Tomlinson, C.W.E、Wild, C、Winokan, M、Xavier, M.-A.E、Fearon, D、von Delft, F.
提交日期：2024-04-04
发布日期：2024-04-24
最后修改日期：2024-10-16
实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.28埃）
引用文献：《柯萨奇病毒A16 2A蛋白酶的晶体学片段筛选发现广谱抗肠病毒研发新机遇》，BioRxiv，2024年