Investigating the expression signatures of circRNA in pulmonary arteial hypertension. Investigating the expression signatures of circRNA in pulmonary arteial hypertension

To investigate the underlying mechanism of pulmonary hypertension, the model of hypoxia-treated pulmonary arterial hypertension (PAH) rats were constructed to detect the differentially expressed profile of circRNAs in lung tissue of PAH rat. The whole genome microarray expression profiling analysis as a discovery platform have been employed to identify genes difference. Overall design: The male rats were exposed to hypoxia (10% oxygen) in a ventilated chamber to induce pulmonary arterial hypertension model, and control rats were exposed to normoxic condition. After 3 weeks late, the lung tissue was collected to detect the circRNA expression profile.