Proteomic analysis using iTRAQ technique to identify global changes in Batten's disease samples using iPSCs derived from keratinocytes and differentiated to iNPCs Three separate mass spectrometry runs
Niemann-Pick disease, type C1 (NPC1) is a fatal, neurodegenerative disorder for which there is no definitive therapy. In NPC1, a pathological cascade including neuroinflammation, oxidative stress and