TCGA Glioblastoma Multiforme (GBM) Gene Expression

Abstract:

The Cancer Genome Atlas (TCGA) was a large-scale collaborative project initiated by the National Cancer Institute (NCI) and the National Human Genome Research Institute (NHGRI). It aimed to comprehensively characterize the genomic and molecular landscape of various cancer types. This dataset contains information about GBM, an aggressive and highly malignant brain tumor that arises from glial cells, characterized by rapid growth and infiltrative behavior. The gene expression profile was measured experimentally using the Affymetrix HT Human Genome U133a microarray platform by the Broad Institute of MIT and Harvard University cancer genomic characterization center.  The Sample IDs serve as unique identifiers for each sample.

Inspiration:

This dataset was uploaded to UBRITE for GTKB project. 

Instruction:

The log2(x) normalization was removed, and z-normalization was performed on the dataset using a Python script.

Acknowledgments:

Goldman, M.J., Craft, B., Hastie, M. et al. Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol (2020). https://doi.org/10.1038/s41587-020-0546-8

The Cancer Genome Atlas Research Network., Weinstein, J., Collisson, E. et al. The Cancer Genome Atlas Pan-Cancer analysis project. Nat Genet 45, 1113–1120 (2013). https://doi.org/10.1038/ng.2764

U-BRITE last update: 07/13/2023