Study on the role and mechanism of magnesium-calcium-mineralised collagen composite scaffolds in the adjuvant treatment of cervical cancer

One of the most prevalent malignant tumor in women was cervical cancer. However, chemoradiotherapy had many side effects and drug resistance. High-quality biomaterials for tumor therapy should have the characteristics of killing and inhibiting tumor growth and light toxic side effects. Magnesium alloy had been widely concerned as a biological bone implant material, and magnesium showed considerable promise in the anti-tumor field as well. The primary breakdown products of composite scaffolds made of magnesium alloy were magnesium ions, hydroxides and hydrogen, which can increase apoptosis and suppress growth in cervical cancer by increasing the accumulation of oxidative free radicals and increasing tumor extracellular pH. In this study, we prepared magnesium alloy/mineralized collagen scaffolds and tested their performance, and vitro and vivo experiments were conducted to study the anti-tumor action mechanisms of magnesium alloy/mineralized collagen inhibits invasion and metastasis, which provided experimental basis for the development of degradable anti-tumor adjuvant therapeutic materials.宫颈癌是女性最常见的恶性肿瘤之一。临床主流的放化疗手段常伴随诸多不良反应与耐药性问题。高品质的肿瘤治疗用生物材料应兼具杀伤、抑制肿瘤生长的能力与轻微的毒副作用。镁合金作为生物骨植入材料已受到广泛关注，而镁在抗肿瘤领域亦展现出可观的应用前景。镁合金复合支架的主要降解产物为镁离子、氢氧化物与氢气，其可通过提升氧化自由基积累量、调节肿瘤细胞外pH值，促进宫颈癌细胞凋亡并抑制其增殖。本研究制备了镁合金/矿化胶原复合支架并对其性能进行表征，通过体外及体内实验探究了镁合金/矿化胶原抑制肿瘤侵袭与转移的抗肿瘤作用机制，可为可降解抗肿瘤辅助治疗材料的开发提供实验依据。