Genomic profiles of tremolite-induced malignant peritoneal mesotheliomas developed in rats

Intraperitoneal injection of tremolite initiates mesothelial injury and chronic inflammation that causes the development of malignant mesothelioma (MM). We performed high-resolution comparative genomic hybridization to identify characteristics in the genomic profiles of tremolite-induced MMs in rats. The carcinogenesis protocol was performed by intraperitoneal injection of 10 mg of tremolite in F1 hybrid (crossing Brown-Norway and Fischer344) rats. Genomes of 8 malignant peritoneal mesothelioma were profiled on Agilent 180K rat genome CGH microarrays.