Structure of 23S rRNA of the large ribosomal subunit from Deinococcus radiodurans in complex with the macrolide erythromycylamine

Structure of 23S rRNA of the large ribosomal subunit from Deinococcus radiodurans in complex with the macrolide erythromycylamine Descriptor: (3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-10-AMINO-6-{[(2S,3R,4S,6R)-4-(DIMETHYLAMINO)-3-HYDROXY-6-METHYLTETRAHYDRO-2H-PY RAN-2-YL]OXY}-14-ETHYL-7,12,13-TRIHYDROXY-4-{[(2R,4R,5S,6S)-5-HYDROXY-4-METHOXY-4,6-DIMETHYLTETRAHYDRO-2H-PYRAN-2-YL]OXY }-3,5,7,9,11,13-HEXAMETHYLOXACYCLOTETRADECAN-2-ONE, 23S rRNA Authors: Pyetan, E, Baram, D, Auerbach-Nevo, T, Yonath, A. Deposit date: 2006-12-03 Release date: 2007-12-04 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (3.6 Å) Cite: Chemical parameters influencing fine tuning in the binding of Macrolide antibiotics to the ribosomal tunnel TO BE PUBLISHED

耐辐射奇异球菌（Deinococcus radiodurans）核糖体大亚基23S核糖体RNA（23S rRNA）与大环内酯类（macrolide）红霉素胺（erythromycylamine）的复合物结构，其配体的结构描述符为：(3R,4S,5S,6R,7R,9R,10S,11S,12R,13S,14R)-10-氨基-6-{[(2S,3R,4S,6R)-4-(二甲氨基)-3-羟基-6-甲基四氢-2H-吡喃-2-基]氧基}-14-乙基-7,12,13-三羟基-4-{[(2R,4R,5S,6S)-5-羟基-4-甲氧基-4,6-二甲基四氢-2H-吡喃-2-基]氧基}-3,5,7,9,11,13-六甲基氧杂环十四烷-2-酮。
作者：Pyetan, E、Baram, D、Auerbach-Nevo, T、Yonath, A
提交日期：2006-12-03
发布日期：2007-12-04
最后修改日期：2023-08-30
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率3.6埃（Å）
引用文献：《大环内酯类抗生素与核糖体隧道结合的精细调控化学参数》（待发表）