Allen Mouse Brain Atlas

The Allen Mouse Brain Atlas is a genome-scale collection of cellular resolution gene expression profiles using in situ hybridization (ISH). Highly methodical data production methods and comprehensive anatomical coverage via dense, uniformly spaced sampling facilitate data consistency and comparability across >20,000 genes. The use of an inbred mouse strain with minimal animal-to-animal variance allows one to treat the brain essentially as a complex but highly reproducible three-dimensional tissue array. The entire Allen Mouse Brain Atlas dataset and associated tools are available through an...艾伦小鼠脑图谱（Allen Mouse Brain Atlas）是一套采用原位杂交（in situ hybridization, ISH）技术获取的、具有细胞分辨率的基因组级基因表达谱集。其采用严谨规范的数据生产流程，结合密集且均匀间隔的采样策略实现了全面的解剖学覆盖，确保了超过20000个基因的表达数据具备一致性与可比较性。该数据集选用个体间差异极小的近交系小鼠品系开展实验，可将小鼠脑本质上视为一套复杂但可高度复现的三维组织阵列。整套艾伦小鼠脑图谱数据集及其配套工具均可通过某一渠道获取。

搜集汇总

背景与挑战

背景概述

Allen Mouse Brain Atlas是一个基因组规模的细胞分辨率基因表达图谱，使用原位杂交技术，涵盖了超过20,000个基因和650,000张图像，专注于小鼠大脑的神经生物学研究。该数据集通过公开的基于网络应用程序和AWS S3存储桶提供，数据一致性强且可比较，适用于基因表达和成像分析。