Single-cell transcriptome analysis reveals evolving tumor microenvironment induced by immunochemotherapy in nasopharyngeal carcinoma

18 bulks and 11 single-cell RNA sequencing samples from paired before anti-PD-1 contained treatment and on treatment in patients with treatment-naive high-risk metastatic locally advanced NPCs were obtained. We aim to explore the mechanism of response heterogeneity for locally advanced NPCs underwent immunochemotherapy.