FBXL12 Reorchestrated Microglial State to Inhibit Scarring and Achieve Adult Spinal Cord Injury Repair (PRJCA042426)

Targeting overexpression of FBXL12 in microglia contributed to its homogeneous distribution and maintained it with a scar-free healing phenotype. FBXL12 therapy effectively reduced extracellular matrix deposition and decreased scar area. Axons grew through the epicenter, significantly improving the motor function and reconstructed the neural circuit. Our results identified FBXL12 as an effective target for a novel microglia-based approach to facilitate scar-less functional recovery in SCI.