Transcriptome sequencing wide functional analysis of human hepatocellular carcinoma in response to BRD4 inhibition

We investigated that differentially expressed genes (DEG) targeted by BET inhibitors, JQ1 and OTX-015 in HCC cells using RNA sequencing. These DEGs are involved in HCC cells migration, of which SMARCA4 inhibition is effective in suppressing HCC cell migration. Overall design: The gene expression profile was performed with control HepG2 (Con), JQ1-treated HepG2 (JQ1), OTX-015-treated HepG2 (OTX). Samples were generated by deep sequencing, in triplicate, using Illumina HiSeq 2500.