S2 File -

S1–S7 Supplemental Tables. This file includes Supplemental Tables. S1 Table. Clinical ICD Codes Used to Define Prevalent and Incident Outcomes. Table of all ICD 9 and 10 codes used to define prevalent and incident outcomes from electronic health record data in CATHGEN. ICD, International Classification of Diseases. S2 Table. Transcripts, genes and variants used for CHIP calling. Table of 68 genes, relevant variants and transcripts used for variant calling. S3 Table. Statistical Analysis Approach. Summary of the statistical analysis approach for prevalent and incident outcomes. Basic covariates = Age, Sex, Ancestry, Smoking; *included in sensitivity model for CAD; HF phenotypes include HF with reduced ejection fraction (HFrEF, EF S4 Table. 463 CHIP variants identified in CATHGEN. Variant level details for the 463 CHIP variants identified in 427 CATHGEN participants. S5 Table. Associations of CHIP with prevalent cardiometabolic disease. Overall, large CHIP and gene-specific analysis for associations of CHIP with prevalent cardiometabolic disease. *Associations for obese vs. non-obese participants defined as body-mass index (BMI) ≥30 mg/kg2. Multivariate analyses are adjsuted for age, sex, ancestry and smoking. ^Multivariate analyses for coronary artery disease (CAD) are adjusted for age, sex, ancestry, smoking, diabetes, BMI, hypertension and hyperlipidemia. CAD sensitivity model included statin use for participants with medication data available. #Multivariate analyses for heart failure (HF) and atrial fibrillation (AF) are adjusted for age, sex, ancestry, smoking, diabetes, BMI, hypertension, hyperlipidemia, prevalent CAD and history of malignancy. AF models are additionally adjusted for prevalent HF. S6 Table. Associations of CHIP and time-to-overall mortality. Overall, large CHIP and gene-specific analysis for associations of CHIP and time-to-overall mortality in CATHGEN. *Cox proportional hazard (PH) models for time-to-overall mortality. Multivariate model includes age, sex, ancestry, smoking, diabetes, hyperlipidemia, hypertension, obesity, prevalent coronary artery disease, heart failure and atrial fibrillation. S7 Table. Fine-Gray associations of CHIP and incident clinical outcomes. Competing risk regression models for incident clinical outcomes with overall mortality as a competing risk. *Multivariate models for incident cardiovascular (CV) outcomes are adjusted for age, sex, ancestry, smoking, diabetes, hypertension, hyperlipidemia, body-mass index, prevalent coronary disease (CAD) and heart failure (HF). Models for MI or CV death and HF hospitalization are also adjusted for prevalent atrial fibrillation. (XLSX)