Crystal Structure of Rabbit Anti-HIV-1 gp120 V3 Fab 10A3 in complex with V3 peptide ConB
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Crystal Structure of Rabbit Anti-HIV-1 gp120 V3 Fab 10A3 in complex with V3 peptide ConB Descriptor: CALCIUM ION, Envelope glycoprotein gp120 V3 peptide of Con B sequence, Heavy chain of Fab fragment of rabbit anti-HIV1 gp120 V3 mAb 10A3, ... Authors: Pan, R, Kong, X.-P. Deposit date: 2017-03-17 Release date: 2018-01-17 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Increased epitope complexity correlated with antibody affinity maturation and a novel binding mode revealed by structures of rabbit antibodies against the third variable loop (V3) of HIV-1 gp120. J. Virol., 2018
兔抗HIV-1 gp120 V3抗原结合片段(Fab fragment)10A3与V3肽ConB复合物的晶体结构 描述项:钙离子、Con B序列包膜糖蛋白gp120 V3肽段、兔抗HIV-1 gp120 V3单克隆抗体(monoclonal antibody, mAb)10A3的Fab片段重链…… 作者:Pan R、Kong X.-P. 提交日期:2017年3月17日 发布日期:2018年1月17日 最后修订日期:2024年11月6日 实验方法:X射线衍射(分辨率1.9埃) 引用文献:表位复杂度提升与抗体亲和力成熟相关,且抗HIV-1 gp120第三可变环(V3)兔抗体的结构揭示了全新结合模式,《病毒学杂志》(J. Virol.),2018年



