Structure of Mcl-1 in complex with compound 8a

Structure of Mcl-1 in complex with compound 8a Descriptor: (2~{R})-2-[[6-ethyl-5-(1~{H}-indol-4-yl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 Authors: Dokurno, P, Szlavik, Z, Ondi, L, Csekei, M, Paczal, A, Szabo, Z.B, Radics, G, Murray, J, Davidson, J, Chen, I, Davis, B, Hubbard, R.E, Pedder, C, Surgenor, A.E, Smith, J, Robertson, A, LeToumelin-Braizat, G, Cauquil, N, Zarka, M, Demarles, D, Perron-Sierra, F, Geneste, O, Kotschy, A. Deposit date: 2019-03-11 Release date: 2019-08-07 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2 Å) Cite: Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. J.Med.Chem., 62, 2019

化合物8a与诱导髓系白血病细胞分化蛋白Mcl-1（Induced myeloid leukemia cell differentiation protein）的复合物结构
描述符：(2R)-2-[[6-乙基-5-(1H-吲哚-4-基)噻吩并[2,3-d]嘧啶-4-基]氨基]-3-苯基丙酸
作者：Dokurno, P、Szlavik, Z、Ondi, L、Csekei, M、Paczal, A、Szabo, Z.B、Radics, G、Murray, J、Davidson, J、Chen, I、Davis, B、Hubbard, R.E、Pedder, C、Surgenor, A.E、Smith, J、Robertson, A、LeToumelin-Braizat, G、Cauquil, N、Zarka, M、Demarles, D、Perron-Sierra, F、Geneste, O、Kotschy, A
提交日期：2019-03-11
发布日期：2019-08-07
最后修改日期：2024-01-24
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2 Å
引用文献：《以结构为导向发现具有细胞活性的选择性Mcl-1抑制剂》，J.Med.Chem., 62, 2019