RNA Binding Protein SRSF3 confers an essential role in megakaryocyte maturation and platelet production. RNA Binding Protein SRSF3 confers an essential role in megakaryocyte maturation and platelet production

RNA sequencing was performed to identify gene expression changes following SRSF3 depletion in mouse bone marrow megakaryocytes and peripheral blood platelets. Overall design: Low (8N) or high (≥16N) ploidy bone marrow megakaryocytes and peripheral blood platelets were isolated from adult Pf4Cre-Srsf3fl/fl and control mice and RNA-sequencing was performed.