Data from: Nonresonant SABRE provides an additional versatile hyperpolarization approach in magnetic resonance

Hyperpolarization approaches in magnetic resonance overcome sensitivity limitations imposed by thermal magnetization and play an important role in a wide range of modern applications. One strategy, SABRE, uses parahydrogen to form hydride transition metal complexes, followed by reversible exchange to polarize target molecules in solution. SABRE has produced large signal enhancements (up to 104) on many different molecules, cheaply and rapidly. Here, we demonstrate an unconventional strategy for SABRE hyperpolarization, applicable to a wide range of targets, that produces field-independent spin order in target molecules which efficiently converts to magnetization. The observed signal is even independent of field direction, and hyperpolarization can be achieved on a lab bench with no field control. We show this signal arises from creation of two-spin order in target molecules and discuss multiple ways this strategy should expand SABRE generality and efficiency. We also show that, in many cases, the standard assumption that low-field SABRE requires a singlet-only starting state leads to incorrect results.